A team of virus researchers is set to perform studies on H7N9 that may make the bird flu more resistant to drugs and more easily transmitted between humans. The scientists announced their plans today in two major science journals, Nature and Science.
H7N9 first arose in eastern China this spring. Since then, it has killed 43 people and sickened 90 more. The outbreak is now under control, but the research team says the virus could gain traction again this winter flu season, so they want to do so-called gain-of-function studies to learn more about the virus quickly.
Gain-of-function studies are controversial. While it’s normal for international scientists to study disease outbreaks intensely, gain-of-function studies take it another step by making epidemic pathogens more dangerous, if only within labs. When scientists wanted to publish the first gain-of-function studies of H5N1 avian flu in 2011, public outcry led them to stop further studies for more than a year.
In short, it’s a question of whether the risk is worth the knowledge we gain about epidemic flus. Opponents worry that the ability-added viruses could escape from labs by accident and infect people. They also worry that terrorists could use published papers about the studies as recipes for bioweapons.
Proponents say the studies offer information that experiments on viruses in their natural state don’t. For example, researchers will test how many changes are needed to make H7N9 spread more easily than it currently does, to help them predict whether such a change is likely to happen naturally. “If only a few mutations are needed, the risk may be greater than if many changes are required,” Yoshihiro Kawaoka, a pathologist at the University of Wisconsin-Madison, wrote to Popular Science in an email.
